压力反应网络（SRN）连接性与男女担忧程度较高有关，尤其在晚年
Greater Stress Response Network (SRN) Connectivity is Associated with Higher Worry in Men and Women Especially in Later Life
在131名50岁及以上、担忧程度不一的成年人中，静息态fMRI显示SRN连接性越高，担忧严重程度越高（B=23.51，SE=12.12，p<0.05），而SRN-ECN连接性与担忧无关。SRN连接性随年龄增长而降低，但同等连接性下年长者报告的担忧更多。该研究为横断面设计，提示SRN连接性而非SRN-ECN连接性可能是担忧严重程度的主要神经相关因素。
BackgroundLate-life anxiety is common and disabling, with pathological worry as a core feature. The Stress Response Network (SRN: amygdala, bed nucleus of the stria terminalis, paraventricular nucleus), which modulates threat and stress reactivity, and its interaction with the Executive Control Network (ECN), anchored by the dorsolateral prefrontal cortex, which supports emotional regulation via top-down cognitive control, may underlie individual differences in worry severity. We hypothesize higher SRN connectivity to be associated with greater worry severity and that this relationship may be moderated positively by older age, and female sex. MethodsWe recruited older adults with varying worry. Resting-state fMRI was used to compute SRN connectivity and SRN-ECN connectivity. Regression models tested associations between connectivity and worry (PSWQ), anxiety (HARS), and rumination (RSQ), adjusting for age, sex, race, and education. Exploratory models examined age and sex moderation and associations with emotion regulation/suppression and cognitive function. ResultsAmong 131 participants who were [≥] 50 years old, with varying levels of worry severity, SRN connectivity was significantly associated with greater worry severity (B=23.51 (SE = 12.12), p<0.05), whereas SRN-ECN connectivity was not. SRN connectivity was lower with greater age (B=-0.003 (SE=0.001), p=0.04), yet older individuals reported greater worry than younger with comparable connectivity. Greater language domain cognitive function was associated with lower SRN connectivity but higher SRN-ECN connectivity, while greater overall cognitive function was associated with lower SRN-ECN connectivity. Women reported lower use of daily expressive suppression and higher performance across cognitive measures than men. Higher daily use of expressive suppression was not significantly associated with either connectivity measure. DiscussionSRN connectivity, rather than SRN-ECN connectivity, may serve as the primary
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来源：medRxiv 精神医学与临床心理 · medrxiv.org